Different species of phosphatidic acid are produced during neuronal growth and neurosecretion
نویسندگان
چکیده
Emeline Tanguy, Qili Wang, Pierre Coste de Bagneaux, Laetitia Fouillen, Tamou Thahouly, Mohamed-Raafet Ammar and Nicolas Vitale 1 Institut des Neurosciences Cellulaires et Intégratives, CNRS UPR 3212, Université de Strasbourg, 5 rue Blaise Pascal, 67000 Strasbourg, France 2 Laboratoire de Biogénèse Membranaire, UMR-5200 CNRS, Plateforme Métabolome, Université de Bordeaux, 33883 Villenave D’Ornon, France 3 INSERM, 75654, Paris cedex 13, France
منابع مشابه
Diacylglycerol kinase ζ generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation
Phosphatidic acid (PA) is one of the phospholipids composing the plasma membrane and acts as a second messenger to regulate a wide variety of important cellular events, including mitogenesis, migration and differentiation. PA consists of various molecular species with different acyl chains at the sn-1 and sn-2 positions. However, it has been poorly understood what PA molecular species are produ...
متن کاملBioproduction of Indole Acetic Acid by Rhizobium Strains Isolated from Root Nodules of Green Manure Crop, Sesbania sesban (L.) Merr.
Twenty six Rhizobium strains were isolated from root nodules of Sesbania sesban (L.) Merr. collected from different regions of Andhra Pradesh. All the 26 Rhizobium strains produced indole acetic acid (IAA), but maximum amount was produced by only five strains in yeast extract mannitol (YEM) medium supplemented with L-tryptophan. The strains were found to elaborate maximum IAA when fed with 2.5...
متن کاملEpidermal growth factor induces the production of biologically distinguishable diglyceride species from phosphatidylinositol and phosphatidylcholine via the independent activation of type C and type D phospholipases.
An early response to epidermal growth factor in A431 cells is the generation of diglyceride, a physiological activator of protein kinase C. By differentially prelabeling cellular phospholipids with [3H]arachidonate and [3H]myristate, which are incorporated primarily into phosphatidylinositol and phosphatidylcholine, respectively, we have found that epidermal growth factor induces an increase in...
متن کاملDiacylglycerol kinases.
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol kinases. By modulating the activity of these p...
متن کاملCytochrome C and Caspase-3/7 are Involved in Mycophenolic Acid-induced Apoptosis in Genetically Engineered PC12 Neuronal Cells Expressing the p53 Gene
Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil. This study designed to investigate the mechanism of cytotoxicity of MPA on the genetically engineered PC12 Tet Off (PTO) neuronal cells with p53 gene. Alamar Blue (AB) reduction showed concentration-dependent cytotoxicity of MPA on PTO cells with IC50 value of 32.32 ± 4.61 mM. The reactive oxygen species (ROS) generation...
متن کامل